Glutamic Acid Decarboxylase65 (GAD65) Antibodies and Insulin Auto-Antibodies in Japanese Patients with Nonlnsulin-Dependent Diabetes Mellitus.
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منابع مشابه
Glutamic Acid Decarboxylase65 (GAD65) Insulin Auto-Antibodies in Japanese Patien Insulin-Dependent Diabetes Mellitus
To clarify whether glutamic acid decarboxylase65 antibodies (GAD65 Ab) and insulin autoantibodies (IAA) are good predictive markers for insulin-dependency in NIDDM, we studied GAD65 Ab and IAA in NIDDM patients treated with diet alone or in combination with oral hypoglycemic agents. GAD65 Ab were found in 12 of 229 (5.2%, P=0.079 vs. control) NIDDM patients and IAA in 8 of 229 (3.5%). The frequ...
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Antibodies directed against the enzyme glutamic acid decarboxylase (GAD) are believed to be the main cause of destruction of pancreatic islet cells in type I (insulin dependent) diabetes mellitus. The enzyme was found both in the brain and pancreatic beta cells. Although similarities in identity of GAD in human and rat brain have been demonstrated, little is known about the interaction betw...
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ژورنال
عنوان ژورنال: Endocrine Journal
سال: 1997
ISSN: 0918-8959,1348-4540
DOI: 10.1507/endocrj.44.43